I've been making vids for quite some time, and have gotten many many comments in my day, so I can't quite remember any that stick out as best/worse. As for best, I get some comments now and then where people say they relate to me in a lot of ways, and I appreciate that
As for worst, this probably isn't it, but a comment I got earlier, that I found amusing. "You made 2000 videos ? Why ? You are the most boring LPing person i've encountered on youtube. Who do you think watches all these videos?"
I tend not to reply harshly, as I don't like stooping to a hater's level, so I responded
"Well, I'm sorry you don't enjoy, I'm sure there are plenty other Lps of this game you might like. But to your question, I'm quickly approaching 10K subs, get 30K views a day and make decent money off of the ad revenue of these videos, plus I really enjoy making them, so there's plenty of incentive for me to keep doing so

"