Right off the bat, you have great video and audio quality. One little criticism: your microphone, although super clear, has a bit of a tinny sound to it. I suggest toying around with it in your audio capture software or your video editor to try and fix it up.
Your commentary is pretty good quality, and your voice is great for it. I recommend making a few little cuts during the more bland parts of gameplay (in Fallout's case, traveling). Although I do like that you have timestamps for some of the more interesting parts!
The last thing I'll touch on is branding. Try playing around in photoshop and design yourself a bright and clean banner that represents your channel. Do the same with a little logo or icon for your profile picture. Your thumbnails are alright but you could use some brighter colours so they stand out from the crowd a bit more!
Hope I could help!