I'm not sure if PX21s will work with PS4 since it requires the component adapter. You would be able to plug the headset directly into the controller via 3.5mm but you will have to unplug the headset from the ampflifier and the result is that you're left with only audio output and no input. You could use the camp if you wanted to but you might find it awkward since the 3.5m and USB plug are so close togheter, you could get extenders but this will cost money. I would recommend waiting to see what new headsets are compatible. I have the PX22s which work great on PS3 but not sure about PS4 since the mic only works if you use the amp from what I'm aware of. Also Turtle Beach might be releasing a new amplifier that might be compatible with the PX2x series so you could wait for that. The new amp is meant to be compatible with next gen via optical since they all use HDMI more.