My two biggest problems are:
1) Getting noticed - I never know where or how I can promote my channel and it's really frustrating. I tend to mostly stick with Twitter these days and have a youtube page and tumblr page on autopilot because those haven't really helped me much at all. People say Reddit but on ALL of the Reddit pages I've tried, even on 'self promotion day' in a couple, my post has been removed. It's really frustrating. I can't even put my website on google ads because google ads insists that there isn't enough content which, imho, is ridiculous.
They say that all you have to do to get noticed is release regular content that's well done and on a reasonable schedule (with keywords) and you'll take off in no time... I've been doing that for over a year and I'm still struggling to hit 300 subs.
2) Getting written off the second I say I'm a gaming youtuber. The channel's so much more than that. I focus heavily on games that tell amazing stories, no matter their genre. They can be classified as an FPS or even a platformer, as long as the story promises to be a good one it goes on the channel. PLUS I've always done my best to promote an open and positive atmosphere for my little community. I've even started releasing vlogs every saturday to tell more of my own story, let folks get to know me a little better, and maybe help people understand issues around chronic illness, gender identity, autism, and other such stuff. But still I get caught up in the sea of children who play fortnight and flood the website with 3 minute clips of them going all 360 Noscope on noobs and whatnot. There are people out there like me who appreciate well told stories in video games, I know they exist... but getting their notice feels like hoping to be found as the needle in a haystack, you know?
Beyond those two - SEOs baffle me. I tried my best with that and I'm still not altogether sure how to work those things properly.... and why is there no ability to copy and paste keywords in the new uploader? I have carpal tunnel and arthritis, dang nabbit, I can't sit here and type out all the keywords on every single video. If it wasn't for Tubebuddy and its list ability for keywords I'd be in wrist braces 24/7